Purified Anti-Human TNF-alpha Antibody[HIXB10] (AN010310P)
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For research use only.
| Alternate Names | APC1, APC1 protein, DIF、TNF-alpha、TNFA、TNFSF2, Differentiation inducing factor, Macrophage cytotoxic factor, macrophage derived, member 2, Membrane Form, monocyte derived, soluble form, sTNFA, TNF superfamily, Tumor necrosis factor alpha, Tumor Necrosis Factor Ligand Superfamily Member, TNFSF, TNF, DIF, TNF-alpha, TNFA, TNFSF2, TNLG1F, TNF alpha, Cachectin, Tumor Necrosis Factor, Tumor Necrosis Factor Ligand Superfamily Member 2, TNF-a |
| Clone | |
| Verified Samples | Verified Samples in FCM: HEK293T cells transfected with pcDNA3.1 plasmid encoding Human TNF-alpha gene |
| Dilution | FCM 2 μg/mL(0.5×106-1×106 cells) |
| Background | This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. Knockout studies in mice also suggested the neuroprotective function of this cytokine. |
| Immunogen | Recombinant Human TNF-alpha protein |
| Abbre | TNF-alpha |
| Swissprot | |
| Host | Mouse |
| Reactivity | Human |
| Clonality | Monoclonal |
| Purification Method | >98%, Protein A/G purified |
| Isotype | Mouse IgG2b, κ |
| Isotype Control | Purified Mouse IgG2b, κ Isotype Control[MPC-11] |
| Applications |
FCM
|
| Research Areas | Cardiovascular Biology;Immunology;Signal Transduction;Cancer;Metabolism;Pyroptosis;Inhibition of Apoptosis;Cytokine and Growth Factors;Death Receptors Signaling Pathway;Insulin Signaling Pathway;Metabolic disorders;NF-kB Signaling Pathway;Pancreatic Cancer Markers;Tumor Biomarkers |
| Cellular Localization |
Cell membrane, Membrane,Secreted
|
| Concentration |
≥ 1 mg/mL
|
| Conjugation | Unconjugated |
| Storage Buffer | Phosphate-buffered solution, pH 7.2, containing 0.05% non-protein stabilizer. Dialyze to completely remove the stabilizer prior to labeling. |
| Storage | Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles. |
| Expiration Date | 12 months |
| Shipping | Ice bag |
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